Decreased Expression of Pulmonary Homeobox NKX2.1 and Surfactant Protein C in Developing Lungs That Over-Express Receptors for Advanced Glycation End-Products (RAGE)
نویسندگان
چکیده
Receptors for advanced glycation end-products (RAGE) are multi-ligand cell surface receptors of the immunoglobin superfamily prominently expressed by lung epithelium. Previous experiments demonstrated that over-expression RAGE murine alveolar epithelium throughout embryonic development causes neonatal lethality coincident with significant hypoplasia. In current study, we evaluated expression NKX2.1 (also referred to as TTF-1), a homeodomain-containing transcription factor critical branching morphogenesis, in mice differentially RAGE. We also contextualized abundance FoxA2, winged double helix DNA binding protein influences respiratory epithelial differentiation and surfactant expression. Conditional was induced mouse gestation (embryonic day E0–18.5), well during saccular period (E15.5–18.5), analyses were conducted at E18.5. Histology revealed markedly less parenchyma beginning canalicular stage continuing period. discovered consistently decreased both FoxA2 lungs from transgenic (TG) compared littermate controls. observed diminished C TG mice, suggesting possible hindered and/or proliferation cells under genetic control these two factors. These results demonstrate must be specifically regulated formation. Perturbation culminating distress perinatal may coincide elevated parenchyma.
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ژورنال
عنوان ژورنال: Journal of developmental biology
سال: 2023
ISSN: ['2221-3759']
DOI: https://doi.org/10.3390/jdb11030033